Medtronic's CoreValve program. International post-market CoreValve Advance study, which will assess up to 1000 patients with severe aortic stenosis implanted with the transcatheter aortic valve system, is underway, ... The primary endpoint of CoreValve Advance is major adverse cardiac and cerebrovascular events 30 days post-procedure, defined as a composite of all-cause mortality, myocardial infarction, emergent cardiac surgery or percutaneous re-intervention and stroke. ...
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